In order to support and inform the work of the ATLAS project and provide evidence-based information on the effectiveness of global interventions to combat CL, FL, and HT, Winrock, supported by LWOB, compiled the Body of Knowledge (BOK). The BOK is a research document that reviews the existing evidence on the effectiveness of interventions in the realms of legal frameworks, enforcement, and coordination. The ATLAS BOK team searched electronic databases for relevant studies published after 2005 and evaluated them for their quality, ultimately choosing 99 studies ranked as “moderate” (44) or “high” (55) quality for inclusion in the review. The identified studies were sorted by topic (legislation, enforcement, or coordination) and assessed to determine whether the interventions achieved their stated objectives, primarily identifying, investigating, referring, prosecuting, and sentencing cases of CL, FL, and HT.